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Wu Y, Yang Y, Zhao W, Xu ZP, Little PJ, Whittaker AK, et al

Without such concerted efforts, the enormous therapeutic promise of ferroptosis modulation may remain confined to the preclinical realm

Typically, high doses (i.e., 5-10 grams) of glutathione are required to increase glutathione levels

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Optimization studies confirmed that ultrasonic irradiation in ethanol offered the best performance, whereas non-polar and aprotic polar solvents were less effective, and polar protic solvents such as isopropanol and methanol led to longer reaction times and lower yields compared to ethanol