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doi: 10.1002/ar.25562 40 LiJQiuS-JSheW-MWangF-PGaoHLiLet al

Figure 3 depicts the relationship between vitamins and the metabolism of Hcy

They are produced through a non-enzymatic glycation process called the Maillard reaction, which uses the carbonyl groups of reducing sugars and the free amino groups of proteins as substrates (Figure 2) (81)

Across human studies and reviews, adverse effects are uncommon at typical supplemental intakes, and when side effects do occur, they are usually mild and gastrointestinal in nature.12 13 44 A safety-focused review published in European Review for Medical and Pharmacological Sciences summarized available clinical and non-clinical data on myo-inositol and reported that only very high intake (around 12g per day) was consistently associated with side effects specifically mild gastrointestinal symptoms such as nausea, gas/flatulence, and diarrhea.44 The authors also noted that the severity of these effects did not increase with higher doses

GSH can also be used as a source of sulfur and cysteine