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Variants of A complexed with Cu(II), including A(1-16), A(1-28), A(1-40), and A(1-42), can catalyze ROS production in the presence of ascorbate, with A(1-42) being the most efficient ROS generator 13

The MT-free and MT-treatment samples were represented as C and M, respectively

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The study found that FOXO4 localizes predominantly in the cytoplasm of Leydig cells in young mice but translocates to the nucleus in aged animals the same FOXO4-p53 sequestration pattern seen in other senescent cell types