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"Your firms corrective actions only included scrapping devices in inventory and increasing the cleaning frequency of the [redacted] machine to prevent excess silicone from migrating to the luer connector, despite receiving 221 complaints and filing 177 [medical device reports (MDR)] for the disconnection of the NAMIC Angiographic Control Syringes from manifolds which impact patients and clinicians, including one (1) MDR # 3015910259-2025-00109 involving the injection of air into a patient (Complaint # [redacted] dated [redacted]) and one (1) MDR # 3015910259-2024-00045 involving biohazard exposure of a clinician (Complaint # [redacted] dated [redacted])." Furthermore, Medline Industries was cited for other violations, including failing to maintain schedules for adjusting, cleaning, and performing other equipment maintenance to ensure compliance with manufacturing specifications

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2.3 Data extraction and synthesis From each eligible study, data were extracted on OSC class and chemical features, biological system (microbial species, host cell type, animal model, or human cohort), exposure conditions, and key mechanistic endpoints (e.g., S-thiolation, membrane disruption, quorum-sensing inhibition, Nrf2/NF-B modulation)

2003 Dec;56(6):635-8

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