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Similarly, in SLG in which recombination was induced before nerve transection (tamoxifen 1 day prior to transection), acinar cell replacement by SOX2 + progenitors was significantly depleted (~50%) after 14 days (Fig EV3E and F)

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These limitations are particularly critical in AKI, where therapeutic windows are narrow, disease progression is rapid, and off-target systemic exposure may exacerbate adverse effects