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ATTAIN-MAINTAIN An innovative trial evaluating whether orforglipron can maintain weight loss previously achieved with injectable GLP-1 receptor agonists (semaglutide or tirzepatide)

Current attempts such as the CobaSorb Test and tests employing a detectable non-radioactive form of B12 may prove to be reasonable alternatives for the original Schillings Test, and thereby help to solve the most important question: Will this patient need a lifelong treatment with pharmacological doses of B12

Although many studies have shown that APOE4 induces a detrimental phenotype of neuroinflammation, this overall effect might be related to a suppression of the beneficial mechanisms of neuroinflammation

P., Cammalleri, L., and Malaguarnera, M

Victora, C