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Because neuroinflammation and oxidative stress are recognized as two important factors participating in the onset and development of PD, the beneficial roles of the MeDiet could rely on the antioxidant and anti-inflammatory properties of this dietary pattern

In these trials, tesofensine has been associated with significant weight loss compared to placebo, and it has demonstrated effects on appetite suppression, increased metabolism, and fat oxidation

While observational and mechanistic studies suggest that disturbed one-carbon metabolism, elevated homocysteine, and mitochondrial dysfunction may contribute to neurodegenerative pathways, current evidence does not establish a direct causal link between B12 deficiency and Alzheimers disease

doi: 10.1016/j.celrep.2022.111805 100 PlygawkoATKanSCampbellK

Sharma R, Bhate L, Agrawal Y, Aspatwar A