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Over the 12 weeks, the participants were supplemented with either 1 g of LC-L-tartrate and 3 g of leucine per day (LC group) or 4 g of leucine per day as a placebo (PLA group), in a double-blind fashion

Genistein Genistein, an isoflavone found in soy, is another nutrient with inhibitory effects on DNMTs and HDACs

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Notably, three differentially expressed genes (HMGB1, CP, TF), at the single-cell level, encode secreted proteins which may impact the susceptibility of dopaminergic neurons in the SN of PD patients to ferroptosis