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Introduction Androgen-deprivation therapy (ADT) is considered a cornerstone treatment option for prostate cancer, the second leading cause of cancer mortality among North American men ( Despite the significant survival advantage it confers, ADT is associated with numerous adverse effects including increased risk for cardiovascular diseases, diabetes, sexual dysfunction, cognitive, and mood dysfunction, and sleep disturbance ( Metabolomic profiling refers to the comprehensive identification and quantification of endogenous or exogenous small-molecule metabolites ( Cancer-related fatigue is a clinical condition that likely encompasses a multitude of subcategories with different pathogenic mechanisms that lead to the same subjective experience ( Materials and Methods Study Participants This study was approved by the National Institutes of Health (NIH) Institutional Review Board

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