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Adequate maternal folate status protects against neural tube defects and supports proper brain development, while deficiency is associated with persistent alterations in offspring neurodevelopment and an increased risk of obesity and insulin resistance later in life [112,113,114]

10.1111/jfbc.14402 97 WangJ.WangF.YuanL.RuanH.ZhuZ.FanX.et al (2022b)

Upstream regulatory pathways and transcription factors p53 pathway p53 is a master stress-responsive transcription factor that governs cell-cycle arrest, senescence and apoptosis, and its functional inactivation represents a central event in tumorigenesis