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Knowledge transfer from classical inflammatory diseases or diseases that lead to inflammatory processes will likely have a major impact on the therapy of PD, and allow new development and/or a repurposing of drugs that are already available

Liu Y, H-D K, Engel H, Van N, Zhao S, Andreeff M

Similarly, inhibition of CD38 in aged mice boosted NAD + levels, improving exercise capacity, but in this case, no significant changes in mitochondrial biogenesis-related genes were observed 138

Iron metabolism and ferroptosis may induce neurological damage through interactions with the central nervous system, gut microbiota, and brain-gut axis, positioning them as potential therapeutic targets for depression (Figure 3)

K.BauerJ