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Increased vascular permeability follows, causing plasma proteins to leak out and form a temporary extracellular matrix

In 2022, 389,485 new OSCC cases and 188,230 related deaths were reported worldwide, yielding a case-fatality rate of 48%, and its incidence continues to rise annually ( 2 Research progress on ferroptosis in OSCC 2.1 Mechanisms of ferroptosis Ferroptosis is a regulated form of cell death driven by the iron-dependent accumulation of lethal lipid peroxides

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In brain-targeted delivery, DTR can serve as a potential target for delivering drugs or therapeutic molecules to specific brain cells by conjugating them with DT or its derivatives [74]

Loss of liver PSAT1 attenuated the increased in serine and glycine 13 C-labeling by SAAR (Fig