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Using NSAs we then identified 43/658 (6.53%) with ALD

Hyperglycemia drives the accumulation of advanced glycation end products AGEs, which activate the RAGE/MAPK signaling axis, thereby inhibiting Col-II synthesis and promoting a catabolic state in chondrocytes (31)

Results: Of the 73 patients, 46 (63.0%) had a single lung metastasis with/without intrahepatic lesions, and 55 (70.3%) and 25 (34.2%) were accompanied by intrahepatic HCC and vascular invasion of the tumors, respectively