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Pushing past your tolerance window creates exactly the kind of GI mess that makes patients quit the protocol entirely

Johnson EA

Malik M, Camm AJ

Another possible regulatory pathway of P450 by cannabinoids involves indirect influence on the noradrenergic and serotonergic transmission in specific brain regions, such as the locus coeruleus (major noradrenergic brainstem nucleus) and the dorsal raphe nuclei (the largest serotonergic nucleus) (Michelsen et al., 2008