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According to the terms of the review, the panels classified ingredients in three categories as follows: Category I: generally recognized as safe and effective for the claimed therapeutic indication Category II: not generally recognized as safe and effective or unacceptable indications Category III: insufficient data available to permit final classification The second phase is the FDAs review of active ingredients in each class of drugs, based on the panels review of ingredients, public comment, and new data that may have become available

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Both models incorporating sarcopenia (MELD-L3 SMI and Composite Model 2) significantly enhanced predictive accuracy compared to MELD 3.0 alone (AUC: 0.71 vs

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