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In this Article Carrots are root vegetables of the Daucus carota plant

The polymer backbone covalently integrates an L-buthionine sulfoximine prodrug to inhibit glutathione biosynthesis, and the nanoparticle matrix encapsulates an elesclomol-copper complex to promote intratumoral copper accumulation

doi: 10.1016/j.fsi.2019.02.010 140 KumarR.MukherjeeS

The di-tryptophan cross-link may weaken the non-covalent bonds between the SOD1 monomers, triggering enzyme unfolding, oligomerization, and aggregation (Coelho et al., ALS-associated SOD1 mutants produce free radicals (ONOO or OH ) and some mutants lose its catalytic activity, which in turn produces highly unstable intermediate products and tyrosine (Abe et al., 2006)

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