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The output is a single annotated construct view: every potential cryptic site mapped, ranked by accessibility, with suggested point mutations (filtered through AstraDDG for stability impact) that abolish the cryptic site without destabilizing the protein

Several biologic therapies have been developed which block these immune cells, mainly cytokines (TNF-, IL-17, IL-1, IL-23, IL-36), Janus kinases, and chemokines (13)

Liver disease The liver is integral in the detoxification of protein metabolites, production of serum albumin and clotting factors, storage of vitamins and minerals, and metabolism of ingested phytochemicals and drugs

Ma L, Yang X, Yang X, Lu S, Zhang H, Fan Y

These findings provide novel insights for developing new drugs to prevent or treat AF