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2010 Jul;9(3):265-268

2 Ferroptosis 2.1 Definition and characteristics of ferroptosis In 2.2 Molecular mechanisms of ferroptosis 2.2.1 Iron metabolism Iron is an essential physiological element, and its distribution and levels can significantly impact physiological processes ( 2+ ) generates large amounts of hydroxyl radicals through Fenton and iron-catalyzed Haber-Weiss reactions, catalyzing the generation of ROS, which in turn leads to the development of LP ( 2+ is produced through intestinal absorption or erythrocyte degradation and then oxidizes to iron (Fe 3+ )

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This finding contrasts with a recent study that proposed higher M2-type macrophage activity in LC (73)

Further NAPQI reacted in situ with L-cysteine in the presence of 100 mM phosphate buffer at physiological pH, yielding S -(5-acetamido-2-hydroxyphenyl)-L-cysteine (APAP-CYS