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These data indicate that Pimo-positive RGCs have a significantly higher mitolysosome number than Naive RGCs, suggesting that hypoxia is a stimulus for mitophagy in the retina

Subgroup analysis of those subjects having reduced corneal nerve fibers, and therefore more definitive evidence of small fiber neuropathy (37), show that ARA 290 treatment is associated with an increase in corneal nerve fiber density, analogous to the improvement seen after improved metabolic control (42) and after simultaneous pancreas and kidney transplantation (43)

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