Furthermore, our work confirmed previous observations that the reductive metabolism of TNBS by specific flavoproteins, eg, GSSG reductase, generates ROS, including hydrogen peroxide (Grisham et al, 1991)
Surprisingly, this additional activity was not recovered in isolated erythrocytes, but only in serum (Figure 2a)
Future clinical trials specifically designed to evaluate this combination will be essential in determining its safety profile and optimal use
Skeletal and cardiac muscle cell membranes exhibit greater resistance to PLA 2 , although both crude venom and melittin exert toxic effects on the cardiovascular system
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