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In cases where the possibility of developing CVD is significant, it may be imperative to implement pharmacological measures to modify risk factors

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DOI:10.1128/IAI.68.7.4225-4237.2000 139

The core direction of future research should focus on directly verifying the causal relationship between local joint ferroptosis and gut microbiota dysbiosis through germ-free OA mouse models, fecal microbiota transplantation experiments, or conditional knockout models of key genes for chondrocyte-specific ferroptosis (such as GPX4 and ACSL4)

[45] Sarangarajan R, Meera S, Rukkumani R, Sankar P, Anuradha G