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8) Selective tumor accumulation

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However, low adherence as well as limited LDL-C efficacy in HoFH patients with markedly reduced LDL receptor (LDLR) activity, 6 results in a low LDL-C goal achievement in most patients

Many of these pharmacologic agents under investigation are hypothesized to target the direct and indirect mechanisms of neurotoxicity but require additional efficacy and safety data before being recommended for use in clinical practice