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However, such nutrient-based interventions face several developmental bottlenecks, such as limited tissue-specific targeting to the heart, variable systemic bioavailability, and delivery efficiency despite liposomal formulation

GLP-1 and GIP receptor activation produces gastrointestinal effects (nausea, reduced appetite) that are dose-dependent

It works by disrupting the metabolic pathways essential for cell division and growth, specifically inhibiting enzymes like thymidylate synthase, dihydrofolate reductase, and glycinamide ribonucleotide formyltransferase

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