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However, when in close proximity to tumorigenic cells, the healthy fibroblasts are influenced by the signals emitted from these cells and undergo irreversible morphological changes, producing cancer-associated fibroblasts (CAFs)

Does somatic mosaicism account for some sporadic ALS

Ezeldin M, Leonardi M, Princiotta C, et al

Lactate accumulation further suppresses cytokine production, including TNF-, IL-2, and IFN-, through interference with MAPK p38 and JNK/c-Jun signaling pathways [295]