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Additionally, ROS can promote the opening of the mitochondrial permeability transition pore (MPTP), which leads to an efflux of ions and mitochondrial molecules that ultimately cause cell death [73]

Knipp S, Gattermann N, Schapira M, Kferstein H, Germing U

However, it is worth investigating whether AMPK has positive impacts on DKD by inhibiting ferroptosis

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The use of erythema migrans as a surrogate outcome for Lyme disease has not been validated