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Turner RJ, Sharp FR (2016) Implications of MMP9 for blood brain barrier disruption and hemorrhagic transformation following ischemic stroke

However, a detailed analysis will focus on the impact of individual viral proteins on metabolism, assuming that LongCovid-19 syndrome is generated by an active chronic viral infection and interference of viral proteins with host metabolism, as is the case with other viruses that enter a state of chronic active infection, such as EBV ( 2.1 COVID-19 activates multiple autoimmune diseases Autoimmunity appears to be a important component of the symptoms associated with LCS, as evidenced by the presence of various autoantibodies in a significant proportion of patients with both LCS and COVD-19 [29,30]

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Whereafter, the monocytes and macrophages were activated and recruited, resulting in further inflammatory cascade response, ultimately leading to renal injury and tubulointerstitial fibrosis (Chen et al., 2022)