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React Oxygen Species 3:111 Jager T, Ashauer R (2018) How to evaluate the quality of toxicokinetictoxicodynamic models in the context of environmental risk assessment

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Grant & Contract Support Selected Publications Peer-Reviewed Articles Wang Y, Larson MC, Hwang SR, Villa D, Kugathasan L, Kumar A, Joseph A, Brooks TR, Hill BT, Bond DA, Maddocks KJ, Nizamuddin IA, Kahl BS, Danilov A, Argao C, Ruan J, Ryan CE, Merryman RW, Grover NS, Khan NB, Ouchveridze E, Tun AM, Ayyappan S, Mou E, Pongas GN, Lossos IS, Harris ZI, Munoz JL, Young P, Portell CA, Baidoun F, Alhaj Moustafa M, Reagan PM, Banaszak LG, Pophali PA, Velayati A, Greenwell IB, Gerber D, Jain P, Wang ML , Narkhede MS, Mehta A, Stack AC, Messmer MR, Bhansali RS, Barta SK, Moyo TK, Ghosh N, Kamdar MK, Anna J, Stanisic AV, Karmali R, Maurer MJ, Cerhan JR, Cohen JB, Martin P

It usually results in mild and self-limited central nervous system (CNS) depression

mTOR inhibition with rapamycin (sirolimus) robustly induces autophagy, reducing tau and amyloid- aggregation in AD models as well as mutant huntingtin in HD models