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Mitapivat was noninferior to splenectomy for amelioration of anemia and reduction in reticulocyte count (Figure 6B), and both treatments resulted in similar decreases in hemolysis biomarkers such as LDH and total bilirubin (Figure 6C)

Collective data shows that metabolic routes like glycolysis, glutaminolysis and PPP are the major source of energy for the proper functioning of neutrophils which finds altered in diabetes individuals with infections

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