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The lessons learned from astrocyte-targeted strategies provide a natural transition to examining microglia, whose dual role as immune defenders and potential drivers of pathology makes them equally compelling therapeutic targets (Figure 5)

P-gp substrates and inhibitors are structurally diverse, and some peptides (cyclosporine being the most notable example) are potent P-gp inhibitors [11]

This combination enables investigation of synergistic angiogenesis mechanisms and multi-pathway cellular migration in laboratory models

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