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Erythroid Nuclear Factor 2 (Nrf2) Pathway and Induction by Ozone Therapy One of the recent most emphasized actions in the literature on the anti-inflammatory action of ozone is based on its effect on the Erythroid Nuclear Factor 2 (Nrf2), which is a powerful transcription factor located inside each cell of the body. The nuclear factor erythroid 2-related factor 2 (Nrf2) is an emerging regulator of cellular resistance to oxidants

In its active state, it binds and activates its effector proteins such as RAF-Kinases, PI3K and RalGDS and activates several cellular signaling pathways including mitogen-activated protein kinase (MAPK) pathway

The emerging role of lysosomes in copper homeostasis

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