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In a recent, trimodal approach comprising 18 F-FDG-PET, functional MRI and 18 F-DOPA-PET, evidence was found for network-dependent neurodegeneration in PD by recapitulating the impact of nigrostriatal pathway impairment on putaminal dopamine depletion to striatocortical motor circuit dysfunction, thus providing a biomarker for the quantification of disease progression (Ruppert et al

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In the simplest case a bispecific antibody would bind to two adjacent epitopes on a single target antigen, such an antibody would not cross-react with other antigens (as described supra)

doi: 10.3389/fphys.2022.934901

In addition, it was considered that penile hypersensitivity may be one of the main pathologic mechanism of PE 14