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This doesn't mean they're dangerous, but it means the full risk profile isn't established with the certainty that approved drugs provide

In normal RVECs, the immunostaining for VE-cadherin and ZO-1 appeared as a continuous band at the junctions of retinal EC, whereas high glucose dampened and broke the immunostaining pattern (Fig

Genomic correlates of clinical outcome in advanced prostate cancer

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In this case, they stated: "To be eligible for inclusion in the present study, a dog had to have echocardiographic evidence of MMVD, defined as above, and demonstrate at least one risk factor for disease progression (evidence of cardiomegaly, ,