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Tyrosine phosphorylation of IB- activates NF-B without proteolytic degradation of IB-

Alimpi A, Kneevi A, Milutinovi M, et al

In mouse model, all mice developed NASH and HCC after feeding with WDSW for 6 months and 1 year, respectively

This dose of L2-Cmu was based in part on a prior pharmacodynamic (PD) study in which L2-C achieved similar suppression of tumor growth in vivo as Ganitumab 25