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FIGURE 1 2 Methods 2.1 Establishment of a sepsis model Male C57BL/6J mice ( Mus musculus , NCBI Taxonomy ID: 10090), 8 weeks old with a body weight of 20 2 g, were obtained from the Laboratory Animal Center of Harbin Medical University (Certification:SYXK (Hei) 2024-002)

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Interleukin (IL)-1 and CXC chemokines, including CXCL1, CXCL2, and CXCL8 (IL-8), are secreted by activated Kupffer cells

PTH increases the activity and number of osteoclasts in bone , causing reabsorption of calcium from the bone into the blood, increasing serum calcium concentration

Among all of the inflammatory cytokines, TNF- has gained a lot of attention due to its multiple effects in promoting cells death, including receptor-interacting protein 1 (RIP1)-independent apoptosis, RIP1-dependent apoptosis (RDA), and necroptosis (6)