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As a result, patients may experience a significant burden from deficiencies

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PRP (platelet-rich plasma) provides a heterogeneous cocktail of autologous growth factors (PDGF, TGF-beta, IGF-1), but its composition varies from one draw to another

Additionally, the lack of sensation in the feet, often overlooked by patients, can lead to insensate injuries, falls, foot ulceration, and even amputation, underscoring the urgent need for early identification and intervention [2, 14,15,16]