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Therapeutic strategies for targeting ferroptosis It has been over a decade since the term ferroptosis was first introduced, and as research has advanced, several clinical drugs and bioactive pharmacological agents have been identified as modulators of ferroptosis, including inhibitors (Table 2) [113,114,115,116,117,118,119,120,121,122,123,124,125] and inducers (Table 3) [126,127,128,129,130,131,132,133,134,135,136,137,138,139,140]

The metabolic adaptability of Tregs also highlights the complexity of tumor therapy, necessitating simultaneous intervention in metabolic limitations of effector T cells (e.g., glucose competition) and alternative metabolic pathways of Tregs (e.g., lactate utilization) (100)

Claudia Lopez directly

However, because only 10% of G6PDH binds cytoplasmic p53, it is not clear how this inhibition is exerted

Samuelsson B, Morgenstern R and Jakobsson P-J