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All authors read and approved the final manuscript

By the onset of proximal tubule dysfunction apoptosis begins in low number of cells (5%)

typically improves with continued use 2 Skin irritation, stinging, or a warm sensation, especially in those with sensitive skin Increased sun sensitivity tretinoin makes the skin more vulnerable to UV damage

The accumulation factor (equation [7]) assumes that the drug follows a one-compartment model ( Figure 32 B), and the peak concentration prediction assumes that the absorption rate is much faster than the elimination rate