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Biomed Pharmacother 162:114606 Jomova K, Alomar SY, Alwasel SH, Nepovimova E, Kuca K, Valko M (2024) Several lines of antioxidant defense against oxidative stress: antioxidant enzymes, nanomaterials with multiple enzyme-mimicking activities, and low-molecular-weight antioxidants

Lesions may be pruritic or painful and vary in size and distribution

This review first outlines the pathways of MPs exposure through the skin and intestinal absorption, emphasizing that nanoplastics can penetrate the stratum corneum or enter the body via endocytosis and paracellular routes in the intestinal epithelium, damaging both skin and intestinal epithelial barriers, inducing oxidative stress, and causing immune imbalance

The fourth node puts the accent on the biosynthesis of bile acids, with lower levels of cholic and glycocholic acids, which are final products of peroxisomal -oxidation

NRF2 then transcriptionally activates ATG genes, helping to mitigate ROS and maintain homeostasis (60-62)