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& Friese, M.A

Besides, two nitroimidazoles (Koike et al., 2020), itraconazole (Xu et al., 2021), and dichloroacetate (Sun et al., 2021) are also proven to have therapeutic potential through promoting ferroptosis in CSCs

The enzyme is membrane-bound with its active site facing the external side of the cell

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Indeed, in the apolipoprotein E knockout model of atherogenesis, activation of Hcar2 on macrophages promotes cholesterol efflux and reduces atherosclerotic plaque burden [77]