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When NNMT is overactive, it consumes S-adenosylmethionine (SAM) and reduces levels of nicotinamide adenine dinucleotide (NAD+), a critical coenzyme involved in cellular energy production

It contributes to nerve health by supporting the creation of the protective myelin sheath, vital for efficient nerve communication

Quantified Benefits: 66% Reduction in Shedding: Post-surgical graft shedding (shock loss) was reduced from a standard 30% down to only 10%

Key Research Properties: Small molecule NNMT (nicotinamide N-methyltransferase) inhibitor Modulates NAD+ metabolism and methylation capacity Studied in context of energy expenditure and metabolic regulation NNMT is upregulated in obesity