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Insulin resistance is a primary cause of weight gain, especially in individuals with conditions like hypothyroidism and PCOS (Polycystic Ovary Syndrome)

Some patients, particularly those with neurological involvement, may benefit from more frequent dosing (every 2 months rather than 3 months), but this should be medically supervised rather than self-adjusted

Muscle tissue also is highly vascularized, which means it contains a lot of blood vessels and allows for the medication to travel into the bloodstream quickly