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Description

Development of novel ALOX15 inhibitors combining dual machine learning filtering and fragment substitution optimisation approaches, molecular Docking and dynamic simulation methods

M.SkrzynskiC

Exposure to CuO nanoparticles (NPs) for up to 24 h in epithelial lung cells (A549) showed very high cytotoxic effects, including lysosomal pathway activation, lysosomal dissolution, significantly increased oxidative damage, and autophagic cell death (Moschini et al., 2013)