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HIV-1 protein Vpr increases H 2 O 2 production and activates hypoxia-inducible factor-1, thereby stimulating HIV-1 gene transcription via hypoxia-inducible factor-1 association with the HIV-1 long terminal repeats 122

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Byrav DSP, Medhi B, Prakash A, Chakrabarti A, Vaiphei K, Khanduja KL (2013) Comparative evaluation of different doses of PPAR- agonist alone and in combination with sulfasalazine in experimentally induced inflammatory bowel disease in rats

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These observations highlight the need for large-scale, multicenter, randomized, placebo-controlled trials to ascertain whether targeted modulation of specific probiotic strains or other gut microbes associated with a lean phenotype can effectively counteract obesity and improve insulin sensitivity