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Daily use for 12 weeks reportedly gives better results than sporadic use for 6 months

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Using mitragynine as a surrogate of the complex mixture, inhibition of intestinal and hepatic CYP3A (time-dependent and reversible) and hepatic CYP2D6 (reversible) by mitragynine was incorporated into the model based on in vitro observations

For long term storage, vials should be maintained at 4 F (20 C) or below and protected from heat, moisture, and direct light exposure