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The results suggest that both A375 and B16F10 cells overexpressed TYR, which is about 1.4-fold and 1.8-fold higher than that in normal melanocytes, respectively (Supplementary Fig

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The smaller magnitude of effect on liver fat, HbA1c and lipoprotein profile for BIO89-100 with every-other-weekly dosing appears to limit the value of extending the dosing regimen (299)