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Mitochondria supply one-carbon units Mitochondrial folate metabolism helps generate formate and other one-carbon units that support cytosolic nucleotide synthesis and methyl-group metabolism

In murine models, intravenous injection of CD117/LNP-Cre achieved gene editing within 24 h, with sustained expression persisting over the subsequent 4 months

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Zucker N, Von Holle A, Thornton LM, Strober M, Plotnicov K, Klump KL, Brandt H, Crawford S, Crow S, Fichter MM, Halmi KA, Johnson C, Kaplan AS, Keel P, LaVia M, Mitchell JE, Rotondo A, Woodside DB, Berrettini WH, Kaye WH, Bulik CM

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