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50 Atypical antipsychotics, including risperidone (a dopamine antagonist) and aripiprazole (a dopamine agonist), are FDA-approved drugs that have been shown to relieve irritability symptoms such as aggression and self-mutilation in adolescent autistic patients in several large clinical trials

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Overall, men using PT-141 will self-administer a subcutaneous shot on demand, ~45 minutes before sex, and should not redose for at least 24 hours