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Mn is distributed across multiple tissues, including the liver (1.32 mg/kg), pancreas (1.17 mg/kg), bones (1 mg/kg), and kidney (0.98 mg/kg) (ONeal and Zheng, 2015

In addition, capsaicin (CAP), another gut microbiota metabolite, alleviates ventilator-induced lung injury by activating Sirtuin 3 (SIRT3) to inhibit ferroptosis and maintain mitochondrial redox homeostasis (129)

Furthermore, its role in the immune response is exemplified in cystic fibrosis

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That caveat established, the preclinical signal is unusually consistent across independent research groups and across a wide range of injury models, which is why the scientific conversation around BPC-157 continues to accelerate