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Further, Wenyu Huang and colleagues identified a causal association linking T2DM with altered lipid profiles, specifically lower HDL-C levels and elevated LDL-C and TG levels (257)

High FIB-4 pts had higher alcohol use, HIV, hepatitis, & comorbidities such as hypertension, heart/kidney disease, PVD and stroke

The PI3K/AKT/mTOR pathway is activated by CD147 to up-regulate HIF-1-mediated glycolysis, and CD147 inhibits PPAR-mediated FAO by activating the MAPK pathway, which eventually leads to drug resistance in cancer cells [86]