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After excluding 5 duplicates in the StArt program, 805 articles were discarded based on title, abstract and keywords ( Figure 1

10.1542/peds.2008-2445 21

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Of note, the arousal stimulator noradrenalin, whose concentration in brain peaks during daytime, has been shown to induce oxidative stress and apoptosis in cultured oligodendrocyte progenitors (Khorchid et al., 2002), whereas acetylcholine that is elevated during the wake state and REM sleep, has been shown to promote mitotic expansion of oligodendrocyte progenitors (Paez-Gonzalez et al., 2014

doi: 10.3389/fncel.2024.1360195 Received 22 December 2023 Accepted 23 February 2024 Published 13 March 2024 Volume 18 - 2024 Edited by Ting Li, Lanzhou University, China Reviewed by Hansen Chen, Stanford University, United States Kimberly S